They produce greater weight loss, require weekly injections, and have broader NHS availability
Red flag symptoms requiring urgent medical attention include: Severe abdominal pain , particularly if constant, progressively worsening, or localized to a specific area Persistent vomiting lasting more than 24 hours or containing blood Signs of pancreatitis : severe upper abdominal pain radiating to the back, often accompanied by nausea and vomiting Right upper quadrant pain, fever, or yellowing of skin/eyes , which may indicate gallbladder disease (a known risk with GLP-1 RAs) [7] [11] Severe, persistent constipation with abdominal distension and vomiting , which could suggest ileus (intestinal obstruction) Inability to pass gas or stool , severe bloating, cramping pain Unexplained weight loss beyond expected therapeutic effects Difficulty swallowing or sensation of food getting stuck Black, tarry stools or blood in stool , which may indicate gastrointestinal bleeding Call 911 or seek emergency care for severe, worsening abdominal pain, signs of gastrointestinal bleeding, or inability to keep fluids down for more than 24 hours with signs of dehydration
doi:10.1016/j.atherosclerosis.2018.07.016 67
From the non-GLP RA group, 2,332,778 were excluded, resulting in 9,103,212 patients
Male mice exhibited losses in both skeletal muscle and organ mass, whereas female mice preferentially lost fat and organ mass while preserving skeletal muscle
