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GLP-1 RAs activate GLP-1 receptors in the nucleus accumbens and the ventral tegmental area, which represent a key reward pathway, as well as modulate energy intake and expenditure by activating anorexigenic proopiomelanocortin (POMC)/cocaine and amphetamine regulated transcript (CART) neurons and inhibiting orexigenic neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons in the arcuate nucleus (2427)

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