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When released (e.g., with vesicle depletion by reserpine or amphetamine) [69,70,152] it can substitute disturbed dopamine (i.e., shortage (reserpine) [69] or excess (amphetamine) [70]) as competing successfully for sites at dopamine receptors (i.e., counteracting the adverse effects of both dopamine agonists [70,152,153] and dopamine antagonists [68,70,152])

a ) Study design for acute COVID cohort

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The affinity-purified shelterin was then subjected to multiple rounds of SEC, using a Superose 6 Increase 10/300 column equilibrated with the SEC buffer (50 mM HEPES pH 8.0, 300 mM NaCl, 5% glycerol, 1 mM TCEP) to further purify and polish the complex