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The drugs need to be taken life-long

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PMID 17043022

Numbing Cream Applied Prior to Treatment For most patients, a prescription numbing cream containing lidocaine is applied 30-45 minutes before the procedure to numb the area

This distinction is now unnecessary, because evidence points to a B 12 absorption pathway independent of intrinsic factor, and studies have proved that oral replacement is equal in efficacy to intramuscular therapy.9 Regardless of the test result, successful treatment can still be achieved with oral replacement therapy