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Clinically, the treatment strategies during phase I utilize conventional methods: patients should be treated with hypothermia, free radical scavengers (e.g., melatonin, erythropoietin, coenzyme Q10), excitatory amino acid receptor blocking agents, and/or neuroprotective agents
Pernicious anaemia, atrophic gastritis, proton pump inhibitors, metformin, and gastrointestinal surgery significantly impair B12 absorption