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Shah F, Bell IM (2020) Cutaneous adverse events caused by sulfonamide-containing drugs: reality or perception

Indeed, the stronger relationship between elevated circulating homocysteine levels and atherothrombotic disease observed in retrospective case-controlled studies than in prospective studies might be explained by the younger average age of subjects sustaining a coronary event in retrospective studies (in the positive study by Wald et al (1998), see the age comparison between retrospective and prospective studies)

Gut microbiota-derived metabolites and cardiovascular disease risk: A systematic review of prospective cohort studies

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This was based on 9 studies