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Despite the immunosuppressive microenvironment of lymphangiogenic tumors mediated in part by LEC antigen presentation-induced T cell tolerance (94, 95, 98), they are more sensitive to systemic immunotherapy due to the elevation of CCL21 in LECs, which promotes the retention of nave T cells and DCs in lymphangiogenic tumors via CCL21/CCR7 chemokine axis (100)

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[DOI] [PubMed] [Google Scholar] 36.Eba S., Hoshikawa Y., Moriguchi T., Mitsuishi Y., Satoh H., Ishida K., Watanabe T., Shimizu T., Shimokawa H., Okada Y., et al

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