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In vivo half-life studies In hemizygous human FcRn Tg32 mice, groups of male mice (78 weeks, 21.530.5 g, 45 mice/cage/group) were given IV injection, into the lateral tail-vein, of 1 mg/kg of unfused WT albumin and QMP albumin variants, diluted in DPBS (pH 7.4) (Sigma-Aldrich)
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In observational studies, CKD and dialysis patients who received calcitriol or synthetic vitamin D analogs (active forms of vitamin D that do not require the kidney for activation) exhibited reduced cardiovascular and all-cause mortality (Zheng 2013)
receptor agonist
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