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Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

The recycling step from GSSG back to GSH depends on an enzyme named glutathione reductase , which requires NADPH to work

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while berbamine (BBM) reduces ACC/FAS/SCD1 expression and decreases hepatic TG and TC content by approximately 50% through the SIRT1/LKB1/AMPK pathway (Sharma et al., 2021)