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There are many factors to consider

Dexpramipexole is a small molecule traditionally developed as treatment for amyotrophic lateral sclerosis

However, this approach is not without limitations, including glucocorticoid resistance, the occurrence of numerous adverse effects, suboptimal drug delivery, and other complicating factors that collectively necessitate the pursuit of innovative therapeutic avenues [6]

TB-500 is commonly discussed as a synthetic fragment related to thymosin beta-4, a naturally occurring peptide involved in cell migration, actin regulation, and wound-healing biology