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Zinman B, Wanner C, Lachin JM et al (2015) Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes

Many doctors prefer to take GLP-1 medications off the table temporarily while the colon heals

Open Cardiovasc

Preliminary analysis of logistic regression showed that age [adjusted OR = 1.06 (1.021.09)], gender [adjusted OR = 2.86 (1.475.60)], number of combined oral drugs [adjusted OR = 1.94 (1.632.31)], history of gastrointestinal disorders [adjusted OR = 4.92 (2.3910.12)], eGFR [adjusted OR = 1.02 (1.001.04)], and BMI [adjusted OR = 1.06 (0.991.14)]

Updated multi-society guidance aligns with broader recommendations which prioritize individualized risk factors for aspiration and other complications, rather than dosing frequency alone