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This led to the discovery that a single mechanism could determine if a single vortex or multiple vortices developed;the softer the gas rotating at the bottom of the vortex is, the smaller that vortex is

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The ASA recognized this and updated their pre-procedure guidance accordingly

12,13,14,15,16,17 Unfortunately, for much of the subsequent 20th century, these concepts became superseded by the neurone doctrine, such that glial responses to CNS disorders were considered to be non-specific, stereotypic, always subsequent to primary neuronal damage and of little functional consequence