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195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death

To view or add a comment, sign in As discussed earlier, the brain is undoubtedly a key missing organ in current clinical frameworks of obesity

Dermatologic Therapy, September 2017, pages 293-304 2

Elevated extracellular calcium activates the calcium-sensing receptor (CaSR), triggering Akt signaling to stimulate proliferation in skeletal metastatic PCa cells [29]

Current global status of male reproductive health