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ICD-10 defines residual schizophrenia as a chronic stage of the illness, in which there has been a progression from an early stage with positive psychotic symptoms to a later stage characterized by long-term negative symptoms and impairments, but reduced frequency and severity of positive symptoms [43]

Tanase DM, Gosav EM, Radu S, Costea CF, Ciocoiu M, Carauleanu A, Lacatusu CM, Maranduca MA, Floria M, Rezus CJIjoms

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So any risk, even if small, should be avoided

Alpha arbutin works nicely in routines that also include hydration, because dehydrated skin can look flat and rough even when tone is improving