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Meta-analyses show berberine reduces body weight by approximately 2-3 kg (4.5-6.5 pounds) over 12-16 weeks, with improvements in fasting blood glucose, insulin sensitivity, and lipid profiles
Kidney overload: High levels of vitamin B12 require the kidneys to work harder to eliminate it, which could lead to kidney stress and, in severe cases, kidney damage
It plays a specific and well-defined metabolic role: it transports long-chain fatty acids across the mitochondrial membrane so they can be oxidised for energy
However, substantial research is needed to expand their utility, optimize delivery methods, and improve patient outcomes
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