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According to the Wegovy SmPC and NHS commissioning policies, treatment should be discontinued if a patient has not lost at least 5% of their initial body weight after 12 weeks on the maintenance dose of 2.4 mg

doi: 10.1016/S0735-1097(19)32472-6

Placenta 128:116122

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Tirzepatide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 due to rodent-based carcinogenicity signals in preclinical studies