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Lipotropic compounds interact with fat metabolism by either hastening the removal or decreasing the amount of fat in the liver

doi: 10.1038/d41586-021-01204-7 5 BuechlerMBPradhanRNKrishnamurtyATCoxCCalvielloAKWangAWet al

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Since semaglutide impacts hormones like insulin and glucagon, which regulate blood sugar levels, shifting hormone levels can lead to a feeling of tiredness