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But when it occurs in pregnancy or the perinatal period, it can affect a babys developing brain

An in vitro study on the interactions of pycnogenol with cisplatin in human cervical cancer cells

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Epidermal PIH may resolve better and faster than dermal PIH where melanin accumulates in long-lived melanophages [27]. Melasma is also a chronic acquired hypermelanosis which involves increased melanin levels in the epidermis and/or dermis [28,29,30]. It manifests as bilateral dark or grayish-brown macules, more particularly located on the face