Cooking tomatoes increases the bioavailability of lycopene, so incorporating cooked tomato-based dishes into the diet enhances its skin-protective benefits
Phytotherapy Research, 29 (8), 1123-1130
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Several groups are developing strategies to improve the bioavailability of PTL, without having detrimental effects on its pharmacokinetic properties.1915 PTL can be successfully sequestered into nanoscopic vectors which can achieve equivalent toxicity to unmodified PTL.1816 Nanoparticle PTL formulations can be used in vivo at 40-fold lower doses with 20-fold lower administration frequency than standard PTL.16 Some of these delivery systems are inexpensive and formulations are readily scalable.18 Consequently, they should facilitate the use of PTL at clinically relevant doses
In parallel, synthetic biology approaches explore LR3 analogs with modified IGF-1R affinity, increased selectivity versus the insulin receptor, or biased activation of specific signaling pathways (pMAPK versus pAkt) to dissociate proliferative from metabolic effects
