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The metabolic benefits extend to prevention of obesity-related comorbidities including type 2 diabetes

Some studies suggest the quinolinium structure is sufficiently NNMT-selective that it should not broadly deplete SAM, but the wider metabolic picture remains an active research consideration

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In the F2 generation, LC3 protein expression was markedly diminished in both low- and high-dose groups relative to controls ( Figures 7AC ), and IF corroborated the reduction in LC3 intensity ( Figures 7D, F )

Immunity 21 , 179188 (2004)