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It is believed this potential protective effect of living with obesity in older adults is restricted to those living only with overweight/lesser degrees of obesity [7], hence the rationale for pharmacological intervention to treat excess weight in older adults is a relevant therapeutic consideration as it would be in younger people

This mechanism becomes maladaptive in diabetes, however as hyperglycemia rise the expression and activity of sodium-glucose cotransporter (SGLT2) in the proximal tubule of the kidney

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A break ensures the endocrine system stays resilient and avoids long-term suppression