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The part that's less clear is whether the clinical benefits in humans match the theoretical promise, especially for longevity-specific outcomes as opposed to treating disease states

[1] In this study, subjects received oral GPLC at a dosage of either 1.5 or 4.5 grams per day over the course of an eight-week intervention period

Here is the honest evidence status up front: the individual compounds have real human data Tesamorelin is an FDA-approved prescription drug (EGRIFTA) for HIV-associated lipodystrophy, and Ipamorelin has been characterized in human GH-release studies but the fixed Tesamorelin + Ipamorelin blend as sold for research has no completed human randomized controlled trial of its own

Heritability of nonalcoholic fatty liver disease

N-acetylcysteine protects ovarian follicles from ischemia-reperfusion injury in xenotransplanted human ovarian tissue