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Calculation of Alzheimers disease (AD)-associated microglia signature scores For each single MG transcriptome, the AD-associated MG signature score was calculated using the AddModuleScore function in the Seurat package, as the average normalized expression levels of top 100 upregulated genes in AD-associated MGs 20 subtracted by the aggregated expression of control feature sets 1

GLP-1 receptors are distributed throughout the body, including in the pancreas, gastrointestinal tract, heart, kidneys, and notably, the central nervous system

this causes slowed energy production, and results in us having less energy

18 October 2017