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Abbreviations AE: Adverse event BMI: Body mass index CFR: Code of Federal Regulations CI: Confidence interval CSF: Cerebrospinal fluid EHR: Electronic health record GI: Gastrointestinal GIP: Glucosedependent insulinotropic polypeptide GLP-1: Glucagonlike peptide-1 GLP-1 RA: GLP-1 receptor agonist GRADE: Grading of Recommendations, Assessment, Development and Evaluations ICD-10: International Classification of Diseases, 10th Revision ICP: Intracranial pressure IIH: Idiopathic intracranial hypertension IQR: Interquartile range NKCC1: NaKCl cotransporter 1 OCT: Optical coherence tomography ONSF: Optic nerve sheath fenestration OR: Odds ratio PMD: Perimetric mean deviation PRISMA: Preferred Reporting Items for Systematic Reviews and MetaAnalyses RA: Receptor agonist RCT: Randomized controlled trial RNFL: Retinal nerve fiber layer ROBINS-I: Risk Of Bias In Nonrandomized Studies of Interventions RR: Risk ratio SAE: Serious adverse event SD: Standard deviation References Mollan SP, Grech O, Alimajstorovic Z et al (2020) New horizons for idiopathic intracranial hypertension: advances and challenges

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In HCC driven by obesity and nonalcoholic steatohepatitis, the downregulation of CPT2 leads to the accumulation of acylcarnitines, among which C18:1-carnitine enhances spheroid formation by HCC cells through STAT3 activation, indicating that the accumulation of acylcarnitine can promote the development of liver cancer [212]