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The SURMOUNT-5 trial showed that maximum-dose tirzepatide produces about 47% more weight loss than maximum-dose semaglutide, so they are clearly not equivalent at their respective maximums

Indications and Patient Selection In the United States, MOUNJARO is FDA-approved as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes mellitus

Less common side effects In some people, metformin causes blood glucose levels to drop too low

Researchers continue to examine Tirzepatide for its role in metabolic signalling, appetite-regulation pathways, glucose-response modelling, and body-composition related studies

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