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Furthermore, many in vitro studies have shown that GLP-1RAs may attenuate or suppress the expression of various inflammatory factors, including TNF-, IL-6 and endothelial adhesion molecules (46, 47)

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An InBody scan at 46 weeks identifies early disproportionate lean mass loss before it becomes clinically significant, allowing dietary intervention before it progresses

Since it reduces appetite, dietary changes may affect the gut microbiome by consuming too little food or lacking variety, which may decrease beneficial bacteria, explains Gans

The trials, NCT06588296 (TOGETHER-PsA) and NCT06864026 (TOGETHER AMPLIFY-PsA), assessed ixekizumab with and without tirzepatide