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Common digestive side effects include: Nausea (affecting up to 44% of patients in clinical trials) Diarrhoea (approximately 30% of patients) Constipation (around 24% of patients) Vomiting (reported by roughly 24% of patients) Abdominal pain, bloating, and dyspepsia Gastro-oesophageal reflux symptoms These effects are typically most pronounced during dose escalation and often improve as the body adapts to the medication

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Strategies for Managing Nausea and Digestive Discomfort To deal with stomach side effects, try changing your diet and maybe the timing of your medicine

A recent study evaluating gastric emptying with tirzepatide (Mounjaro) and oral contraceptives found that a single 5mg dose of tirzepatide was associated with an approximate 20% decrease in the amount of the oral contraceptive absorbed into the bloodstream