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Based on this model, CerS1 is transported to the outer mitochondrial membrane by the p17/PERMIT to recognize and induce C18:0 ceramide-mediated mitophagy in brain (Oleinik et al., 2023)
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SS-31s effects on muscle tissue make it particularly relevant for active patients and athletes: Improved lactate clearance: mitochondrial efficiency affects how quickly lactate accumulates during high-intensity exercise and how quickly it is cleared during recovery Reduced exercise-induced oxidative stress: the oxidative stress generated by intense exercise is substantially mitochondrial in origin
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7), which played a key role in SP@M-mediated RA alleviation
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