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Small Molecule Why Injectable Semaglutide Requires a Needle Injectable semaglutide (Ozempic/Wegovy) is a peptide-based medication

In a pharmacodynamic study using a HFD-induced obesity mouse model, the MN patch significantly reduced the size of fat pads, increased overall energy expenditure, and improved metabolism

[DOI] [PubMed] [Google Scholar] Cree-Green et al

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On the other hand, the risks of HHF (HR 0.93, 95% CI 0.831.04 with GLP-1RAs and HR 0.69, 95% CI 0.610.79 with SGLT2is) and composite kidney outcomes excluding macroalbuminuria (HR 0.92, 95% CI 0.801.06 with GLP-1RAs and HR 0.55, 95% CI 0.480.64 with SGLT2is) significantly reduced with SGLT2is only