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Nausea, vomiting, diarrhoea and constipation can also make it harder to eat a varied diet, particularly when starting treatment or increasing the dose

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Setmelanotide Approved from age 2, but limited to specific genetic disorders (e.g., biallelic POMC, LEPR, Bardet-Biedl syndrome) [108], and may be used in this age range (genotype-restricted)

Participants were randomly assigned to receive weekly injections of retatrutide at doses of 1 mg, 4 mg, 8 mg or 12 mg, or a placebo for 48 weeks