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To directly implicate NOTCH1 mutations, we engineered an MEC-1 model to generate wild-type (MEC-1/N WT ) or mutated (MEC-1/N M ) clones in a UM-BCR background

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doi:10.1016/j.freeradbiomed.2007.01.006 Bouderba S, Sanz MN, Sanchez-Martin C, El-Mir MY, Villanueva GR, Detaille D, Koceir EA (2012) Hepatic mitochondrial alterations and increased oxidative stress in nutritional diabetes-prone Psammomys obesus model