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Its widely used in neurosurgery anesthesia due to its ability to reduce cerebral blood flow, decrease cerebral oxygen consumption, and decrease intracranial pressure, which could exert powerful convulsive effects [74]

Squeeze out a small amount

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Acknowledgments The authors would like to thank Dr Jeremy Hancock, Mr Paul Virgo and staff of Bristol Genetics Laboratory, Southmead Hospital for excellent technical assistance

324,366,367,368,369 However, complete prohibition of purine intake is not recommended due to its limited effect on serum uric acid levels (approximately 1 mg/dL) and the significant burden it imposes on patients