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Vascular dysfunction serves as the primary underlying cause of cardiovascular illness occurrence in patients experiencing anomalous glucose metabolism

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ROS generated by mitochondria, particularly in response to cellular stress, act as signaling molecules that amplify necroptosis through promoting RIPK1/RIPK3/MLKL activation

The polyphenols of catechin, quercetin, and ethanol exert supportive effects against vascular disease, which can be explained by increased fibrinolytic activity and expression of the proteins involved in fibrinolytic system (Sedighi, Bahmani, Asgary, Beyranvand, & Rafieian-Kopaei, 2017)

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