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However, peptide therapeutics have historically been limited to parenteral administration, with successful oral delivery remaining a largely unresolved challenge due to unfavorable molecular properties that limit their ability to overcome gastrointestinal barriers (Hamman et al., 2005)

Outside the PNS, expression of peripherin was highest in the ileum, but with more than 31-fold lower expression relative to the trigeminal ganglion, and with even lower to absent expression in the cerebellum, cerebral cortex, midbrain, kidney, testis, pituitary, adrenal gland, stomach, duodenum, jejunum and colon (Extended Data Fig

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S., & Namdeo, A

PMCID: PMC6950543