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11 12 This raises concerns about potential long-term effects on metabolic health, strength, and physical function

Weight loss achieved through caloric restriction is accompanied by marked elevation in circulating ghrelin (145), which increases feeding drive and has therefore been ascribed as a natural defense against weight loss

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108, 118 This is not surprising, given that the species-specific diet in mice is very different from humans who are omnivores and during much of their evolution consumed low-glycemic load diets

10.1038/s41586-020-2732-8 205 ZouY.HenryW