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A correlation between the angiogenic profile and the response to immune-checkpoint blockade (ICB) was reported (118, 152, 153) and anti-angiogenic treatments were shown to enhance the efficacy of immunotherapies (154156)

Medicine (Baltimore) 2017;96(13):e6426

Furthermore, ROS disrupt the transmission of nitrergic neurotransmitters by causing nitrergic neuron death and decreasing neuronal nitric oxide synthase (nNOS) signaling, leading to endothelial dysfunction [142144]

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