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Notably, obesity is associated with a higher risk of depression, and neuroimaging studies show DMN abnormalities in both

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Histone deacetylases (HDAC2), a member of the HDAC family, is correlated with insulin signaling components in postsynaptic glutamatergic neurons of the adult mouse hippocampus, and hyperactivity of the HDAC system (including HDAC2) may result in the suppression of the insulin signaling system and consequent disruption of synaptic plasticity in type 2 diabetes.137 GLP-1 RA has a definite effect on improving synaptic plasticity