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It was reported that 125 I-labeled exogenous Klotho is located mainly in the kidney, with much lower levels in other organs, including the spleen, liver, heart, and brain ( via transcytosis by renal proximal tubules (Lim et al., 2015

1 In patients with PD, cell loss occurs in the substantia nigra with the formation of Lewy bodies (intracellular neuronal inclusion bodies)

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The report also cited adverse event reports involving symptoms such as severe gastrointestinal distress, vomiting, fainting, tachycardia, and injection-site complications