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3 Ferroptosis and neurodegenerative diseases Iron is an essential trace element for maintaining brain function, playing vital roles in neuronal development, neurotransmitter synthesis, mitochondrial energy metabolism, myelin formation, and synaptic plasticity (Gao et al., 2025)

Several enzymes involved in ATP production contain Fe-S clusters in the active site and are subject to similar inactivation by superoxide, including oxoglutarate dehydrogenase of the tricarboxylic acid cycle, as well as ETC complexes IIII

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Many of these lawsuits will ultimately group together multiple plaintiffs who have similar claims against Novo Nordisk for issues related to Semaglutide so that common issues can be litigated in common, resulting in expense sharing to the benefit of the claimants

Furthermore, this study was not able to assess the impact of DNA methylation on gene transcription, as RNA sequencing was not performed