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In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

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An increase in red blood cells increases the bloods ability to transport oxygen to the peripheral system, ensuring greater maximum aerobic capacity [194]

The pathways may overlap, but current evidence does not show one confirmed sequence in which BPC-157 activates all of them in a fixed order

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