Recently, the author and his colleagues reported hyperinsulinism prevalence of 75.1% in 684 patients from a general population in New York metropolitan area (ref
del MonteFWilliamsELebecheDSchmidtURosenzweigAGwathmeyJKet alImprovement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure
In this group of people, the type of vitamin B supplement given is important and a supplement with active forms of folate and B12 should be used (L-methlyfolate (5-MTHF) and methylcobalamin)
Yes, many patients with IBS-D tolerate semaglutide well because slower gastric emptying can reduce urgency and improve stool consistency

Sources New England Journal of Medicine: TripleHormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial New England Journal of Medicine: Once-Weekly Semaglutide in Adults with Overweight or Obesity Eli Lilly: News Release: Lillys phase 2 retatrutide results published in The New England Journal of Medicine Clinical Trials Arena: Eli Lilly infiltrates anti-obesity market as Phase III trial for retatrutide begins Eli Lilly: News Release: Lillys tirzepatide shows additional 21.1% weight loss after 12 weeks of intensive lifestyle intervention, for a total mean weight loss of 26.6% from study entry over 84 weeks Semaglutide FDA Labels: Tirzepatide FDA Labels: Important Medical Information and Disclaimers Medical DisclaimerThis article, Retatrutide Weight Loss Results: Retatutride vs Tirzepatide vs Semaglutide , is for educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment