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A BMI of 25 or higher around the index date Prior engagement (one or more outpatient encounters more than one year prior to index overdose AND one or more outpatient encounters after index overdose) Study population: exclusion Patients with: An assault-related overdose (ICD-10-CM code T* with 7th character = 3) A GLP-1 order prior to their first overdose encounter A methadone overdose (ICD-10-CM code T40.3X*) diagnosis Index date First qualifying overdose encounter (ED or inpatient) which must occur within the study period

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biotechs (Metsera, now-Pfizer