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Studies have revealed a family aggregation tendency in patients with RA that is potentially linked to genetic factors such as the human leukocyte antigen (HLA) gene, PTPN22 gene, and TRAF1-C5 gene, among others [28]

doi:10.1007/s11325-017-1461-1

While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)

Birth Control Depletes Folate You need folate for cells to divide and reproduce, as well as to remove the chemical homocysteine that is dangerous to your cardiovascular system