Quick Answer: Tirzepatide does not directly cause sleeplessness as a recognised adverse effect, though sleep disturbances may occur indirectly through gastrointestinal symptoms or metabolic changes
In April 2025, the pharmaceutical giant sued Empower Pharmacy specifically, alleging that the company was marketing unapproved tirzepatide compounds using misleading claims
Other notable side effects include injection site reactions (redness, itching, or swelling at the injection site), fatigue, and hypoglycemia, particularly when tirzepatide is used in combination with insulin or sulfonylureas
When to contact a healthcare provider Most injection-related issues resolve on their own within 24 to 48 hours
March 30, 2026 Tirzepatide vs Semaglutide: A Comprehensive Comparison for Providers Share this post Key Takeaways Semaglutide is a GLP-1 receptor agonist, while tirzepatide works on GIP and GLP-1