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A 2021 review published in Nutrients found that GLP-1 receptor agonist use was associated with reduced dietary intake of multiple micronutrients including B12, particularly in patients following calorie-restricted eating patterns, supporting the rationale for monitoring B12 status during treatment even in patients without pre-existing deficiency risk factors

The Phase 2 data proves it: fast escalation to 8 mg doubled GI adverse event rates compared to gradual titration

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So compared to the amount that we usually recommend