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Baccharin (3-prenyl-4-(dihydrocinnamoyloxy) cinnamic acid): Derived from Brazilian propolis, baccharin is a natural product with a unique structure, displaying high potency and isoform-selective competence in suppressing AKR1C3 activity (IC 50 = 0.10 M, 510-fold selectivity for AKR1C3 over AKR1C2) (Zang et al., 2015)

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