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Rotate the injection site each time to prevent irritation and lipohypertrophy [9]

Its worth noting that the copper ion isnt just along for the ride

Individuals with Poor Absorption: People with low stomach acid, or those who have had certain surgeries (like gastric bypass), may struggle to absorb B12 from food and would benefit from injections

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These pain-relieving effects are blocked by drugs that affect norepinephrine, but not serotonin, suggesting that the pain relief works through adrenergic pathways (9)