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While these differences may sometimes seem subtle, variations in gastric pH, gut motility, gut enzymatic activity, and transporter protein expression can contribute to sex-based differences in drug absorption, affecting how efficiently a drug reaches its target site (see Table 1)

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One unit of enzyme activity was defined as 1 mol of NADH oxidized/min at 25C

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3A), among which 317, 567 and 631 DEGs were up-regulated, and 327, 504 and 367 DEGs were down-regulated (Fig