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Research literature suggests that this axis is not governed by linear onoff signaling, but rather by pulsatile, context-sensitive interactions shaped by feedback loops and receptor specificity

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The trials primarily included individuals with preexisting cardiovascular disease, which may limit the applicability of the results to a broader audience

Healthcare providers first began using stimulants, such as Adderall, for weight loss after noticing their ability to produce decreased appetite and weight loss as side effects