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The financial cost: Adults with obesity spend an average of $1,861 more per year in medical expenses than those at a healthy weight, according to CDC data

However, they target different hormone receptors and work through slightly different mechanisms

Metabolic and bariatric surgery should be discussed with patients who have BMI 35 kg/m (regardless of comorbidities) or BMI 30-34.9 kg/m with metabolic disease, according to 2022 ASMBS/IFSO guidelines

Standard clinical practice is to administer the first tirzepatide dose (2.5 mg) on the same injection day the semaglutide dose would have been due, then escalate tirzepatide at the label-specified 4-week intervals regardless of what semaglutide dose the patient was on

But it can also feel emotionally strange if food previously played a large role in comfort, celebration, social connection, or stress relief